She was a thoroughly accomplished princess, fluent in Spanish, Catalan, Italian, and French, which prepared her for advantageous marriage to any European monarch or prince, and literate in both Latin and Greek.

Unlike most educated women of her time, for whom convents were the primary source for knowledge, her education came from within the sphere of intellectuals in the court and close relatives, and it included a solid grounding in the Humanities, which the Catholic Church was reviving at the time. Her education would primarily take place in the Piazza Pizzo de Merlo, a building adjacent to her father's residence. During her early life, Lucrezia Borgia's education was entrusted to Adriana Orsini de Milan, a close confidant of her father.

Her mother was Vannozza dei Cattanei, one of the mistresses of Lucrezia's father, Cardinal Rodrigo de Borgia (later Pope Alexander VI). Lucrezia Borgia was born on 18 April 1480 at Subiaco, near Rome. Rumors about her and her family cast Lucrezia as a femme fatale, a role in which she has been portrayed in many artworks, novels and films. Alfonso of Aragon was an illegitimate son of the King of Naples and tradition has it that Lucrezia's brother Cesare Borgia may have had him murdered after his political value waned. Her family arranged several marriages for her that advanced their own political position including Giovanni Sforza, Lord of Pesaro and Gradara, Count of Cotignola Alfonso of Aragon, Duke of Bisceglie and Prince of Salerno and Alfonso I d'Este, Duke of Ferrara. She reigned as the Governor of Spoleto, a position usually held by cardinals, in her own right. Lucrezia Borgia ( Italian pronunciation: Valencian: Lucrècia Borja 18 April 1480 – 24 June 1519) was an Italian noblewoman of the House of Borgia who was the daughter of Pope Alexander VI and Vannozza dei Cattanei. Francesco d'Este, Marquis of Massalombarda

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